Study on severe acute respiratory syndrome seroepidemiology after its outbreak in a general hospital
- VernacularTitle:天津某医院严重急性呼吸综合征暴发期间血清流行病学调查
- Author:
Zhen YANG
;
Hai-Ke DU
;
Bin SU
;
Ying JIN
;
Xue-Mei DONG
;
Shi-Xin WANG
;
- Publication Type:Journal Article
- Keywords:
Severe acute respiratory syndrome;
SARS Virus;
Seroepidemiologic studies;
Antibodies,viral;
Immunoglobulin G;
Immunoglobulin M
- From:
Chinese Journal of Infectious Diseases
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To study the level and development of serum specific antibody against severe acute respiratory syndrome coronavirus(SARS-CoV)of different populations in SARS pestilence district after SARS outbreak in a general hospital.Discuss SARS sub-clinical infection and protective action of the IgG antibody.Methods Seroepidemiology method,enzyme-linked immunosorbent assay (ELISA)and indirect immunfluorescence assay(IFA)were employed to investigate the changing level of serum antibody to SARS-associated coronavirus in non-SARS population in SARS pestilence district during and after SARS outbreak.The development of IgM and IgG antibody in patients with SARS in 6 weeks after the onset of SARS was studied qualitatively.The level changing of IgG antibody in con- valescent patients with SARS in 82 weeks after the onset was observed dynamically.Results The ELISA test outcome of IgG antibody was negative in 200 non-SARS people who were random samples of normal mass in SARS pestilence district and common community.The positive rate was 0.41% in 487 SARS high risk population tested by ELISA,but showed negative when retested by IFA.The A value level of IgG antibody existed significant difference in non SARS mass during and after SARS outbreak and the later's was higher them the former's(P
