Diffusion tensor imaging and three-dimensional brain fiber tracking for the diagnosis of multiple sclerosis
- VernacularTitle:扩散张量成像和三维脑白质束示踪在多发性硬化中的临床应用
- Author:
Bing HU
;
Hong SHAN
;
Ming-Yue LUO
;
Shao-Qiong CHEN
;
Zhuang KANG
;
Bing-Jun HE
;
Yan ZUO
;
Bin-Bin YE
;
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Magnetic resonance imaging;
Diffusion;
Leukoencephalopathy,progressive multifocal
- From:
Chinese Journal of Radiology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To demonstrate the diffusion tensor imaging(DTI)characteristics of multiple sclerosis(MS)plaques,periplaque white matter regions and normal appearing white matter (NAWM)regions in patients with MS,and to evaluate the clinical values of DTI and three-dimensional brain fiber tracking for the diagnosis of MS.Methods Conventional MRI and DTI were performed in 32 patients with MS and 32 age-matched control subjects.Fractional anisotropy(FA)and apparent diffusion coefficient(ADC)maps were generated and coregistered with T_2-weighted MR images,FA and ADC values were calculated in regions of interest in plaques,periplaque white matter regions,NAWM regions and white matter regions in control subjects.And three-dimensional brain fiber tracking maps were generated by using the DTI.Results TheADCwas(1.233?0.119)?10~(-3)mm~2/s in MS plaques,(0.973?0.098)?10~(-3) mm~2/s in periplaque white matter regions,(0.748?0.089)?10~(-3)mm~2/s in NAWM,and(0.620? 0.094)?10~(-3)mm~2/s in control subjects.The FA was 0.225?0.052 in MS plaques,0.311?0.050 in perip]aque white matter regions,0.421?0.070 in NAWM,and 0.476?0.069 in control subjects. Significant differences in FA and ADC values were observed among all white matter regions(P
