Correlation between spiral CT features of pericolic infiltration and tumor angiogenesis in colorectal carcinoma
- VernacularTitle:大肠癌肠外浸润螺旋CT征象与肿瘤血管生成的相关性
- Author:
Rui-Ping ZHANG
;
Jian-Ding LI
;
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Neovasularization,pathologic;
Endothelial growth factors;
Tomography,X-ray computed
- From:
Chinese Journal of Radiology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of spiral CT(SCT)features with pathology, microvessel density(MVD)、expression of vascular endothelial growth factor(VEGF)、matrix metalloproteinase-2(MMP-2)in colorectal carcinoma.Methods Forty patients with colorectal carcinoma confirmed by operation were examined by SCT.The resected tumor specimens were immunohistochemically stained for the expression of VEGF,MMP-2 and the calculation of MVD.Results The accuracy of SCT in depicting the pericolic and wall infiltration was 92.5%.The metastasis rates of colorectal cancer with pericolic infiltration and wall infiltration were 75.0% and 33.3%,respectively,the differences were statistically significant between the two groups(P
