Inhibitory Action of Jiangru Power on Rat Prolactinoma Induced by Diethylstilbestrol
- VernacularTitle:中药降乳散对乙烯雌酚诱发的大鼠泌乳素瘤的抑制作用
- Author:
Chun XU
;
Liwu LIANG
;
Xiaojun LIU
;
- Publication Type:Journal Article
- Keywords:
estrogen;
prolactinoma;
rat;
dopamine agonist;
Chinese materia medica;
Jiangru Power
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the inhibitory action of Jiangru Power on rat prolactinoma induced by diethylstilbestrol.Methods: Prolactinoma Rat models were prepared by embedding estrogen subcutaneously.Then they were randomly divided into three groups,respectively given intragastric administration of placebo,Jiangru Power and Norprolac.After four weeks of treatment,all the animals were executed.Each pituitary gland was weighed.Serum prolactin(PRL) levels were measured by RIA method.Pituitary tumor transformed gene(PTTG) mRNA levels in pituitary tissue were measured by RT-PCR method.Results: The weight of pituitary gland and serum PRL level in Jiangru Power or Norprolac group all were obviously lower than those in placebo group(P
