Initial study of quantitative analysis of fatty liver by ~1H-MR spectroscopy imaging
- VernacularTitle:脂肪肝MR氢质子波谱成像定量分析的初步研究
- Author:
Chang-Hong LIANG
;
Yu-Bao LIU
;
Zhong-Lin ZHANG
;
Shu-Fei XIE
;
Qiu-Shi WANG
;
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Fatty liver;
Comparative study
- From:
Chinese Journal of Radiology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of ~1H-MR spectroscopy(~1H-MRS)imaging to quantitatively detect fatty liver.Methods Twenty patients with fatty liver and 11 healthy volunteers underwent plain CT scan,conventional MR imaging and ~1H-MRS analysis.The blood lipid and liver function were tested on the same day as the MR examination.~1H-MRS sequence measured the peaks of H_2O and lipid,and the areas under the peaks.The relative contents of the lipid compound were calculated,and compared with the results of CT scan and liver function tests.Results The CT values of the normal group and the fatty liver group were(59?9)HU and(24?11)HU respectively.On ~1H-MRS a protruding high H_2O peak and a flat low lipid peak were observed in the normal group,while the protruding high H_2O peak and a high lipid peak appeared in the fatty liver group.The values of lipid peak in the normal group and the fatty liver group were(0.05?0.01)?10~5,(0.70?0.24)?10~5 respectively(t=4.32,P0.05),the areas under the lipid peak were(1.36?0.73)?10~9、(2.35?1.15)?10~9 respectively(t=5.21,P0.05).Conclusion ~1 H-MRS imaging is feasible to quantitatively detect liver fat and is a non-invasive method for detecting early fatty liver.
