The Role of Brain-Derived Neurotrophic Factor in the Onset of Vascular Dementia
- VernacularTitle:脑源性神经营养因子在血管性痴呆发病中的作用
- Author:
Bing-Qing ZHANG
;
Yu-Liang WANG
;
- Publication Type:Journal Article
- Keywords:
brain-derived neurotrophic factor;
vascular dementia;
protein-tyrosine kinase B;
synaptic plasticity
- From:
International Journal of Cerebrovascular Diseases
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Vascular dementia,an acquired,persistent syndrome of intelligent disorder,mainly caused by cerebrovascular disease is one of the main types of senile dementia.Its pathogenesis remains unclear.Brain-derived neurotrophic factor sustains multiple neuronic survival,development, differentiation,and repair following injury.It also induces and maintains the long-term potentiation of hippocampus and cortex,and changes the morphologic plasticity of hippocampal neuron by regulating hippocanoal synaptic transmission and synaptic plasticity.It participates in the processes of hippocampus-dependent learning and memory,and it may play an important role in the onset and development of vascular dementia.
