The Role of Selectins in Ischemia-Reperfusion Injury of Brain
- VernacularTitle:选择素在脑缺血再灌注损伤中的作用
- Author:
Gang WU
;
Shi-Ming ZHANG
;
- Publication Type:Journal Article
- Keywords:
selectin;
cerebral ischemia;
reperfusion injury
- From:
International Journal of Cerebrovascular Diseases
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Selectins are a family of adhesion molecules,including P-,L-,E-selectins.The three adhesion molecules all participate in the inflammatory processes of ischemia-reperfusion injury of brain.P-selectin is expressed on activated platelets as well as on endothelial cells.E-selectin is only expressed on endothelial cells.P-and E-selectin mediate the adhesion of the leukocytes,platelets and endothelial cells.L-selectin is mainly expressed on leukocytes and mediates leukocytes rolling contact with microvascular endothelial cells.
