Recent Progress in Research on Small Molecule Agonist of Neurotrophic Factor Receptor Trk
- VernacularTitle:神经营养因子受体Trk小分子激动剂研究进展
- Author:
Lei-Si BIAN
;
Zhen-Guo LIU
;
Wen-An WANG
;
- Publication Type:Journal Article
- Keywords:
neurotrophic factor;
Trk receptor;
agonist
- From:
International Journal of Cerebrovascular Diseases
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Neurotrophic factor activates signal pathways of intracellular phosphoinositide 3-kinase and extracellular signal-regulated kinase after acting on Trk receptor tyrosine kinase.It promotes the survival and differentiation of neurons.The development of small molecule Trk agonists of non-peptides and neurotrophic factor simulants can avoid a number of shortcomings of neurotrophic factors while agitating trk receptor signal transduction.It may provide a novel therapeutic approach for the treatment of nervous system diseases.
