Prospective randomized controlled trial of antibiotic prophylaxis for newly placed peritoneal dialysis catheter to prevent postoperative peritonitis and wound infection
- VernacularTitle:腹膜透析置管术预防性抗生素用药的前瞻性随机对照临床研究
- Author:
Wei CHEN
;
Zong-Pei JIANG
;
Xun-Hua ZHENG
;
Wei-Ying CHEN
;
Qun-Ying GUO
;
Hai-Ping MAO
;
Xiao-Qing YE
;
Xiao YANG
;
Xue-Qing YU
;
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Cefazolin;
Leftriaxone;
Antibiotic prophylaxis;
Wound infection
- From:
Chinese Journal of Nephrology
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of two antibiotic prophylactic regimens in a prospective randomized trial in 1 year for patients undergoing insertion of catheters,and to provide the evidence for uniform consensus existing on the timing,route,and choice of antibiotic.Methods During a period of 12 months,78 patients,who consecutively entered the peritoneal dialysis programme,[45 women and 33 men,mean age (48.2?15.7)years] were included.The prophylactic regimens were a single dose of ceftriaxone (1.0 g) given intravenously 30 minutes before surgery (Group A) and given cefazolin (0.25 g/L) i.p.in the each dialysis bag for 3 days postoperatively (Group B).All operations were performed in one room.The wound was observed every day,and body temperature,Count of white blood corpuscle and type,dialysate were examined every day. Results In Group A and B,none of the patients showed peritonitis or wound infection during the post-operative period (within 10 days).One of 39 patients(2.5%) in the group A,and 2 of 39 patients (5.1%) in the group B had exit site infection (P＞0.05).Conclusions There is no significant difference in the incidence of peritonitis and wound infection between two groups. Prophylactic preoperative single-dose antibiotics intravenously do as well as antibiotics given intraperitoneally for peritoneal dialysis catheter insertion,but is much more convenient.
