Proton MR spectroscopy study in neonates with hypoxic ischemic encephalopathy
- VernacularTitle:新生儿缺氧缺血性脑病的MR波谱研究
- Author:
Wen-Zhen ZHU
;
Jian-Pin QI
;
Cheng-Yuan WANG
;
Li-Ming XIA
;
Li-Wen CHANG
;
Jun-Wu HU
;
Ding-Yi FENG
;
Ming-Li ZOU
;
Yin-Hua ZENG
;
- Publication Type:Journal Article
- Keywords:
Infant,newborn;
Cerebralanoxia,cerebralischemia;
Magneticresonancespectroscopy;
Prognosis
- From:
Chinese Journal of Radiology
1999;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the metabolic alterations in the brain of neonates with HIE and correlate those alterations with clinical grading and prognosis of HIE.Methods Fourty-six eases of full-term neonates diagnosed as HIE clinically were performed MRI and 1~H-MRS,9 healthy neonates without the evidence of asphyxia were studied as controls,1~H-MRS techniques included single voxel proton MRS and two dimensional muhi-voxel chemical shift spectroscopy imaging,point resolved spectroscopy sequence was used for 1~H-MRS.Metabolic changes in the spectroscopy were analyzed in neonates with HIE,and study the relationgship between MRS findings and prognosis.Results(1)The typical 1~H-MRS manifestations of full- term neonates suffering from HIE were as follows:the peaks of Lac were elevated,GLx-? were elevated and NAA were decreased.(2)GLx-?/Cr ratio in control,mild,moderate and severe HIE group was 0.16, 0.21,0.64,and 1.31,respectively.Lac/Cr ratio in control,mild,moderate and severe HIE group was 0.12,0.14,0.19,and 0.26,respectively.There was a significant difference in the ratio of GLx-? and Lac/Cr between HIE group and control group(t=5.01,P
