Effect of Liuweidihuang Granula Cooperating with Flixotide Aerosol on IFN-? and IL-4 of Asthma Rat Models
- VernacularTitle:六味地黄颗粒协同辅舒酮吸入对哮喘大鼠IFN-?和IL-4影响的研究
- Author:
Han LIU
;
Lining WANG
;
Xiaoqi HUANG
;
Liying LIANG
;
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
airway inflammation;
Liuweidihuang Granula;
integrated traditional and western medicine
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of representative formula of nourishing yin and invigorating the kidney(Liuweidihuang Granula) cooperating with Flixotide aerosol inhalation on the allergic airway inflammation of asthma rat models.Methods: Wistar rats were randomly divided into six groups.Except the norma1 control group,all the other 5 groups were sensitized by injecting into the abdominal cavity of the ovalbumin(OVA) together with aluminum hydroxide as adjuvants,2 weeks later followed by aerosolized OVA challenge to prepare the asthma models.From the eighth day of the experiment,in medication administration teams, rats were sprayed with Flixotide aerosol and given intragastric administration with Liuweidihuang Granula.The normal control group and the asthma model group were drenched with normal saline.Results: There was no difference between the groups given Liuweidihuang Granula and different dosages of Flixotide aerosol but the amount of IFN-? and IFN-?/IL-4 in BALF in the Liuweidihuang Granula cooperating with Flixotide aerosol group were higher than that in the model group(P
