Expression of osteopontin and osteonectin in breast cancer and its relationship with formation of microcalcification
- VernacularTitle:乳腺癌组织中骨桥蛋白和骨连接蛋白的表达及其与微钙化形成的关系
- Author:
Guang YANG
;
Xiang-Hong ZHANG
;
Jing ZHANG
;
Zhi-Gang ZHANG
;
Xiao-Ling WANG
;
Xia YAN
;
Jun-Ling WANG
;
Jun-Jing ZHAO
;
Zhi-Gang LI
;
- Publication Type:Journal Article
- Keywords:
Breastneoplasmas;
Calcium-bindingproteins;
Calcinosis;
Mammography;
Causality
- From:
Chinese Journal of Radiology
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of osteopontin(OPN)and osteonectin(ON) in breast cancer and its relationship with formation of microcalcification.Methods Acoording to the number of microcalcification of breast cancer in mammography,93 cases were divided into three groups:non- microcalcification group,little microcalcification group,and much microcalcification group.The relationship between expression of OPN\ON and microcalcification was studied.At the same time,breast cancer with microcalcification was observed in 3 cases by using patho-histological method and transmission electron microscopy(TEM).Results Microcalcification was detected not only in necrosis foci,but also in nest of breast cancer without necrosis.Microcalcification was found in intracytoplasm of breast cancer cells through TEM.Expression of OPN\ON was significant related with the presence and number of microcalcification. There was obviously different expression between microcalcification group and non-microcalcification group (x~2=11.454,5.540,P
