Study on Anti-tumor Activities & Tumor Radio-sensitivity of 17a?-D-Homo-Ethynylestradiol-3-Acetate
- VernacularTitle:17a?-D-高炔雌二醇-3-乙酯抗肿瘤活性及辐射增效作用研究
- Author:
Zewei ZHOU
;
Liang'An ZHANG
;
Xiu SHEN
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
17a?-D-homo ethynylestradiol-3-acetate;
Anti-tumor;
Radio-sensitivity;
Pharmacological activities
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The paper reports anti-tumor activities and tumor radio-sensitivity research of the novel Estrogen compound 17a?-D-Homo Ethynylestradiol-3-Acetate to U_ 14 and S_ 180 sarcomas;and overall test high-activity and low toxicity traits of 17a?-D-Homo Ethynylestradiol-3-Acetate by the indexes of thymus gland,spleen,etc.Methods The mouse cervical cancer U_ 14 was selected and implanted in IRM-2 mice for anti-tumor assay,and sarcoma S_ 180 was selected for tumor radio-sensitivity assay,the drug was administered to all mice by i.v.way.Results 17a?-D-Homo Ethynylestradiol-3-Acetate has obvious anti-tumor activity to U_ 14 tumor,the best inhibitory rates is U_ 14 64.3%,and17a?-D-Homo Ethynylestradiol-3-Acetate has hardly any influence to hematogenous system(spleen index),immune system(thymus index);Nevertheless,the positive control drug CCP has obvious damage to spleen index and thymus index(P
