Significance of serum cytokines concentrations and APACHE scores in evaluating the illness state for Critical patients
- VernacularTitle:血清细胞因子与APACHEⅡ评分的变化在严重创伤患者监测中的意义
- Author:
Hui ZENG
;
Shao-Chuan RUAN
;
Li-Hua CAI
;
Dong-Xin JIANG
;
Bing-Jun TAN
;
Yu-Qing YANG
;
Xiao-Mei YUAN
;
- Publication Type:Journal Article
- Keywords:
SIRS;
APACHE score;
IL-6;
TNF-?
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of serum cytokines concentrations and A- PACHE scores in evaluating the illness state for critical trauma patients.Methods A clinical prospective self-control trial was performed,in which 36 patients admitted to ICU by SIRS were enrolled.Objects were divided into mild and severe trauma group according to APACHE score.The TNF-?and IL-6 concentrations were determined on the 1st, 3rd and 5th day of admission,the APACHE score were assessed at the same time.Statistic analysis was performed according to this group.Results The TNF-?concentrations decreased continuously in the following days while IL-6 decreased from the 7th day in the mild trauma group.In the severe trauma group the TNF-?and IL-6,APACHE score concentrations kept increasing.There was a significant difference of TNF-?and IL-6 concentrations between severe trauma and mild trauma group.Conclusion Dynamic measurement of TNF-?and IL-6 concentrations with APACHE score provide great help to evaluate the illness state and predict the prognosis.
