Ifosfamide and vinorelbine combined chemotherapy in the treatment of advanced non-small cell lung cancer
- VernacularTitle:异环磷酰胺联合长春瑞滨治疗晚期非小细胞肺癌疗效分析
- Author:
Yi LAO
;
Shao-Feng CHEN
;
Gui-Hua LEI
;
De-Ming XU
;
Wei WANG
;
Hai-Ming ZHONG
;
- Publication Type:Journal Article
- Keywords:
Ifosfamide;
Vinordbine;
Antineoplastic combined chemotherapy protcols;
Cancer,non-small cell lung
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate therapeutic effects and toxicity of advanced non-small cell lung cancer (NSCLC)treated by combining chemotherapy on ifosfamide(IFO)and vinorelbine(NVB).Methods 107 cases pa- tients with advanced NSCLC were enrolled.IFO was given in a dosage of 1.5g/m~2 on day 1 to 4.and NVB in a dosage of 25mg/m~2 on day 1 and 8.It was repeated every three or four weeks,up to two to four cycles.Results Two patients had complete response and 40 patients had partial response.The overall response rate was 47.7% ,the median survival time 10.3 months,1-year and 2-year survival rate was 42% and 12.3%,respectively.The main toxicity was bone marrow suppression.Conclusion The regimen is effective,sale and tolerable in advanced non- small cell lung cancer therapy.
