Antithymocyte Globulin/Antilymphocyte Globulin in the Treatment of Nonsevere Aplastic Anemia.
- VernacularTitle:ALG/ATG治疗非重型再生障碍性贫血
- Author:
Quan LI
;
Yong YOU
;
Ping ZOU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Antithymocyte globulin/antilymphocyte globulin;
Anemia,aplastie anemia;
Cyclosporine A
- From:
Chinese Journal of Practical Internal Medicine
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effectiveness of Antithymocyte globulin/antilymphocyte globulin(ATG/ALG)in the treatment of nonsevere aplastie anemia(NSAA)patients who didn't respond to cyclosporine A(CsA)or relapsed and review the literature.Methods We administered ATG/ALG to 5 NSAA patients who relapsed or showed no re- sponse after CsA therapy.Results 3 patients were cured,2 patients improved,4 patients became transfusion inde- pendent in 90 days,none relapsed or progressed to clonal disease.Conclusion Those NSAA patients who relapsed or showed no response after CsA therapy should be asministered ATG/ALG,so as to reduce transfusion complications and prevent sustained immune attack to the bone marrow.
