Influence of early regulating blood lipid on the prognosis and endothelial function in post-PCI acute coronary syndrom patients.
- VernacularTitle:早期强化调脂治疗对介入治疗后急性冠脉综合征患者预后及内皮功能的影响
- Author:
Shuren LI
;
Xiaoyong QI
;
Jianqing ZHANG
;
Tianhong WANG
;
Yi DANG
;
Fuli HU
;
Jie DONG
;
Di WU
;
Liying XUN
;
Xiaoyun ZHAO
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Coronary artery;
Vasodilation
- From:
Chinese Journal of Practical Internal Medicine
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of two different dose of atorvastatin on the prognosis and endothelial function in post-PCI acute coronary syndrom patients.Methods 92 post-PCI ACS patients were randomly divided into two groups,atorvastatin 20mg and atorvastatin 10 mg group.In each group the patients were treated with atorvasta- tin 20mg or 10mg respectively.After one month we add or decrease the dose of atorvastatin according to the blood lipid level.After 12 month the blood lipid level、FMD、NO、ET、NOS、UAP、AMI were compared between two groups. Results The clinical setting have no significant association between two groups before treating,After treated 1 and 12 month the TC,LDL-C level were significantly decreased as compared with the base level before treating in each group. After treated 1 month,in atorvastatin 20 mg group the TC,LDL-C level were significantly decreased and NO、NO/ET level were significantly higher than those in atorvastatin 10 mg group.During 12 month follow up the incidence of angina pectoris onset and rehospitalization were significantly higher in atorvastatin 10 mg group(P
