Correlation between Ile50Val polymorphism of IL-4 receptor gene and susceptibility to asthma.
- VernacularTitle:IL-4受体基因Ile50Val位点多态性与哮喘易感性的研究
- Author:
Bin WU
;
Zeqing SONG
;
Riqiang DEN
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Asthma;
IL-4R;
Gene;
Polymorphism;
IgE
- From:
Chinese Journal of Practical Internal Medicine
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate correlation between Ile50Val polymorphism of IL-4 receptor gene and asthma and the impact on plasm total IgE,sIL-4R level.Methods the DNA is isolated from 2ml venous blood from 100 nomal subject and 100 asthma subject.The genetic polymorphism was identified by Allele-specific PCR techniquers,plasm total IgE,sIL-4R level was determined by ELISA.Results The frequency of genetype is significantly different be- tween control group and asthma group x~2=18.94,P
