A study on the correlation between STAT6 gene+2964 G/A polymorphism and asthma and plasm IL-5 level.
- VernacularTitle:STAT6基因+2964G/A多态性与哮喘及血浆IL-5水平相关性研究
- Author:
Wen LI
;
Dongming LI
;
Min CHEN
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
STAT6;
Gene;
Polymorphism;
Asthma
- From:
Chinese Journal of Practical Internal Medicine
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between+2964 G/A locus polymorphism of IL-5 gene and the impact of the polymorphism upon plasm IL-5 level.Methods polymerase chain reaction/restriction fragment length polymorphism(PCR/RFLP)techniquers were used to determine+2964 locus polymorphism in asthma and control group,and plasm IL-5level were determined by ELISA.Results The frequency of allele G,A of+2964 locus had significant difference between two groups(x~2=17.26,P0.05,In each group,the plasm IL-5 level of subjects with G allele was higher than that of subjects without G allele,the plasm IL-5 level of asthma group was higher than that of control group with same genetype.Conclusion The+2964 polymorphism of STAT6 gene may be an important candidate gene for asthma.G allele is associated with asthma and increases the plasm IL-5 level.
