Serum cystatin C and serum creatinine in evaluation of renal function in kidney diseases.
- VernacularTitle:血清胱蛋白酶抑制剂C对肾功能评价的临床价值
- Author:
Hang LIU
;
Xiangmei CHEN
;
Shuwen LIU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Cystatin C;
Creatinine;
Glomerular filtration rate
- From:
Chinese Journal of Practical Internal Medicine
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate serum eystatin C as a marker of glomerular filtration rate(GFR)in kidney diseases and as screening test to detect reducing of GFR.Methods Serum cystatin C,serum creatinine and urine creatinine were measure in 81 patients with various nephropathies in our hospital.Additionally,serum eystatin C of 100 blood do- nors were measured as normol controls.Results The relationship rate between cystatin C and 24 hours creatinine clean- rance(R=-0.657)is better than between serum creatinine and 24 hours creatinine(R=-0.573).To creatinine cleanrance estimated by Cockcroft-Gault formular(Cockcroft),we also obtain the same results(r=-0.674 vs r=- 0.596).Cystatin C showed a high sensitivity and negative predictive value for detecting impaired glomerular function in patients,but the specificity and positive predictive valuewas slight low.There were no significantly differ between cysta- tin C and creatinine in receive-operating characteristic plot(ROC).Conclusion Cystatin C is a better marker than creatinine to detect reduced GFR as measured by 24 hours creatinine eleanrance and Cockcroft-Gault formular.The ef- ficacy of Cystatin C as a screening test need more confidents.
