A Case of Malignant Peripheral Nerve Sheath Tumor Arising from Neurofibromatosis during Pregnancy.
- Author:
Hyung Dong KIM
1
;
Hyun Jin SHIN
;
Young Lip PARK
;
Kyu Uang WHANG
;
Sang Hyun BAIK
;
Jai Soung PARK
Author Information
1. Department of Dermatology, College of Medicine, Soonchunhyang University, Seoul, Korea. topdoctor@naver.com
- Publication Type:Case Report
- Keywords:
Malignant peripheral nerve sheath tumor;
Pregnancy;
Neurofibromatosis type 1
- MeSH:
Adolescent;
Adult;
Breast;
Cafe-au-Lait Spots;
Female;
Growth Hormone;
Humans;
Neurofibroma;
Neurofibromatoses*;
Neurofibromatosis 1;
Parturition;
Peripheral Nerves*;
Pregnancy*;
Pregnant Women;
Puberty
- From:Korean Journal of Dermatology
2006;44(1):75-78
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Malignant Peripheral Nerve Sheath Tumor is a neoplasm that most often arises in anatomically discernible peripheral nerves or neurofibroma. This rare tumor usually has a strong association with neurofibromatosis type 1. Nearly half of these malignant tumors arise in individuals affected with neurofibromatosis type 1. Neurofibromas often first appear around the time of puberty, increase in size and number during pregnancy, and shrink after giving birth. Because growth hormone (GH) concentration increases during puberty and pregnancy, it is possible that GH influences the growth of these tumors. A 33-year-old pregnant woman presented with a 4-month history of a painful, huge mass growing on the right breast. She suffered from neurofibromatosis type 1, with multiple cafe au lait spots and neurofibromas. The clinical and histopathological findings showed a malignant peripheral nerve sheath tumor. We report a case of malignant peripheral nerve sheath tumor on the right breast in a pregnant woman with neurofibromatosis type 1.
