Toxic Substances Accumulation in Rat Post-hematencephalon and Experimental Study on Deintoxication of New Qingkailing Injection
- VernacularTitle:大鼠脑出血后毒性物质积聚及新清开灵注射液解毒作用的实验研究
- Author:
Min LIU
;
Yi LU
;
Pengtao LI
;
Qingguo WANG
;
Hong XU
;
- Publication Type:Journal Article
- Keywords:
hematencephalon;
toxin;
new Qingkailing injection
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of new Qingkailing injection on the toxic substances accumulation post-hematencephalon.Methods: Using VII-type collagenase inducing rat hematencephalon,the contents of TNF-?,IL-1? and sICAM-1 of brain homogenate were detected by ELISA;the contents of SOD and MDA were determined separately by xanthine oxidase method and thio-barbituric acid method; brain water content was detected by dry-wet weight method;serum NSE content was determined by liquid phase competition method.Results: Inflammatory reaction was fierce 48 h after hematencephalon in rat,and that new Qingkailing injection could effectually lower the contents of the inflammatory factors,MDA,brain water content and NSE,and could heighten the content of SOD.Conclusion: New Qingkailing injection has favorable heat-clearing and detoxicating effects on the pathologic state of flourishing toxic heat post-hematencephalon.
