Effects of ginsenosides on the expression of TrkB mRNA in hippocampal formation of aged rats
- VernacularTitle:人参皂苷对老龄大鼠海马结构TrkB mRNA表达的影响
- Author:
Hong LAI
;
Hai-Hua ZHAO
;
Liang ZENG
;
Ji-Ping YANG
;
Xin FANG
;
Yong-Li LV
;
- Publication Type:Journal Article
- Keywords:
ginsenosides(GS);
hippocampal formation;
TrkB mRNA;
in situ hybridization;
aged rats
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the age-related changes of TrkB mRNA in hippocampal formation of aged rats,and the effects of ginsenosides(GS),and provide reliable experimental evidence for anti-aging.Methods 24 Wistar female rats were randomly divided into 3 groups: Young,aged and GS group(fed with GS from 17 to 27 months).In situ hybridization(ISH) method was applied into qualifying and quantitating the TrkB mRNA expression in hippocampal formation.Results TrkB mRNA expression in aged CA3,CA1 and dentate gyrus decreased by 24.2%,13.4% and 50.6%(P
