Studies on effect of artemether to control infection and prevent acute infection of Schistosoma japonicum in high endemic areas
- VernacularTitle:口服蒿甲醚控制重疫区血吸虫病及预防急性感染
- Author:
Honggen CHEN
;
Dandan LIN
;
Yuesheng LI
;
Yuemin LIU
;
Donald P. Mcmanus
;
Xinghua HUANG
;
Zheng FENG
;
- Publication Type:Journal Article
- Keywords:
Artemether;
Prevention;
Acute schistosomiasis
- From:
Chinese Journal of Schistosomiasis Control
1989;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of artemether in the control of prevalence and acute infection of Schistosoma japonicum in humans in high endemic areas. Methods During the transmission season (May-October), the residents in the pilot village took artemether with a 15- day interval to prevent the infection of S. japonicum. Results By the end of the transmission season, the egg positive rate was 0.83% and no acute case occurred in the artemether group, while 15.01% and 3 acute cases were observed in the placebo group. Conclusions Oral administration of artemether at a 15-day interval shows an effective protection from infection of S. japonicum, with a protection rate of 94.47% in residents of a high endemic area and it also shows marked effect to prevent acute schistosomiasis.
