Effects of propafenone on myocardium inotropism in isolated papillary muscle of guinea pig
- VernacularTitle:普罗帕酮对豚鼠心肌力学的影响
- Author:
Feng BAI
;
Ji-Yuan LV
;
- Publication Type:Journal Article
- Keywords:
propafenone;
myocardium inotropism;
papillary muscle;
guinea pig
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of propafenone on myocardium inotropism and explore it’s possible mechanism in isolated papillary muscle of guinea pig. Methods Developed tension (DT), maximum rate of contraction (+dT/dt_ max) and maxi-mum rate of relaxation (-dT/dt_ max) were measured during propafenone perfusion before and after administration of L-type calcium channel blocker, nicardipine and selective Na+/Ca 2+ exchanger inhibitor, KB-R7943. Results ①At concentration of 0.1,1,10,30 ?mol?L -1,propafenone attenuated DT from control (0.18?0.05) g to (0.14?0.03), (0.12?0.03), (0.08?0.02), (0.05?0.02) g respectively (P
