Prevention Action of Changtong Oral Liquid on Postoperative Intestinal Adhesions in Rabbits
- VernacularTitle:常通口服液对兔术后肠粘连的预防作用
- Author:
Chunxia WANG
;
Lianbing HOU
;
- Publication Type:Journal Article
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the Prevention Action of Changtong Oral Liquid (CTOL) on the postoperative intestinal adhesions in rabbits. Method: Thirty-six male New Zealand rabbits were randomly divided into six equal groups (n=6): Normal control (group 1); model control (group 2); Simo Decoction (group 3); and CTOL minimal, medium and maximal dosages (group 4,5,6). Except group 1, the other rabbits were created as intestinal adhesive models. Group 1 and group 2 were orally fed with distilled water (20ml/kg), and group 3 to 6 with Simo Decoction 10ml/kg and CTOL in doses of 2.15g/kg, 4.30g/kg and 8.60g/kg respectively. On day 3 after surgery, the blood samples were collected to determine the fibrinolytic activity, and on day 9 the adhesion was graded. Result: CTOL could evidently reduce the severity of postoperative adhesions and increase plasma tPA activity and inhibit plasma PAI-1 activity. Conclusion: CTOL could prevent postoperative intestinal adhesion formation.
