The anti-tumor molecular mechanisms of non-steroid anti-inflammatory drugs
- VernacularTitle:非甾体类抗炎药抗肿瘤作用的分子机制
- Author:
Xian-Da REN
;
Yan-Qing LV
;
Kai-He YE
;
Shao-Hui CAI
;
Chun-Ling YE
;
- Publication Type:Journal Article
- Keywords:
non-steroid anti-inflammatory drugs;
cyclooxygenase;
peroxisome proliferator-activated receptor;
neoplasm
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
This review introduced the anti-tumor effects of non-steroid anti-inflammatory drugs (NSAIDs) and summarized their possible molecular mechanisms according to recent abroad literatures and our research results. Some evidence showed that the anti-tumor mechanisms of NSAIDs were different in various tumors.NSAIDs decreased the biosynthesis of PGE_2 and regulated the expressions of downstream correlated genes and proteins through restraining abnormal expression of COX-2 in certain neoplasms,which resulted in the inhibition of tumor angiogenesis and proliferation as well as induced apoptosis. But in other cancer cells, NSAIDs, as activators of peroxisome proliferator-activated receptor ? (PPAR?), induced COX-2 expression, promoted the biosynthesis of cyclopentenone prostaglandins (cyPGs). cyPGs further induced tumor cell apoptosis with PPAR? dependently or PPAR? independently. Since their special mechanisms of anti-proliferation and pro-apoptosis, NSAIDs revealed significant synergistic effects with other anti-tumor treatments.
