The differential expression profile of polycystic ovary syndrome associated genes
- VernacularTitle:多囊卵巢综合征相关基因的差异表达研究
- Author:
Zhen-Xing HU
;
Jie QIAO
;
Mei-Zhi LI
;
Xiao-Wei ZHANG
;
Yong-Jian CHEN
;
Rong LI
;
Chun-Ling SUN
;
- Publication Type:Journal Article
- Keywords:
Polysystic ovary syndrome;
Ovarian granulosa cell;
Microarry;
Gene expression profiling
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the gene differential expression pattern of polycystic ovary syn-drome.Methods:We carried out microarray analysis to define the gene networks by the PCOS granulosacells in order to identify differentially expressed genes in PCOS patients.These granulosa cells of fivePCOS cases and five control cases which were derived during oocyte retrieval from women undergoingIVF.Results:As compared with control human ovarian granulosa cells,46 genes were screened out,25genes were up-regulated,and 21genes were down-regulated in PCOS.These differentially expressedgenes were involved in various biologic functions,such as regulation of fatty acid metabolism,cell-cellsignal transduction,immune and inflammatory response,reflecting the complexity of clinical manifesta-tions of PCOS.Conclusion:Microarray analysis technology is an effective mothod to identify novel PCOSassociated candidate genes.
