Clinical and pathological analysis of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome
- VernacularTitle:原发性胆汁性肝硬化-自身免疫性肝炎重叠综合征患者的临床和病理分析
- Author:
Chi-Hong WU
;
Xiao-Yuan XU
;
Hai-Ying LU
;
Yan-Yan YU
;
Gui-Qiang WANG
;
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
biliary;
Hepati(?)s;
autoimmune;
Retrospective studies
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore clinical and histopathological characteristics of primary biliary cirrho-sis-autoimmune hepatitis overlap syndrome.Methods:Clinical data and pathological findings of 10 pa-tients were reviewed.Results:Serum glutamine transpeptidase,alkaline phosphatase levels,alaninetransaminase,aspartate transaminase,serum IgG and IgM were elevated in all the patients.They were allpositive for anti-mitochondrial antibody and AMA-M2.Nine patients were positive for anti-nuclear anti-body and one patient was positive for anti liver-kidney microsome antibody.Liver biopsies in these pa-tients revealed:ten patients had bile duct lesion,hepatitis activities ranged from moderate to severe,andfibrosis ranged from S1 to S3.Conclusion:PBC-AIH overlap syndrome is mostly found in middle-agedwomen.It has the clinical and histopathological characteristics of both PBC and AIH.Accurate andprompt diagnosis of overlap syndrome patients should be based on the clinical presentation,biochemicaland immune indexes,and hepalic pathological changes.
