Clinical significance of progesterone receptors A and B expressions in endometrial carcinomas
- VernacularTitle:孕激素受体A和B亚型在子宫内膜癌中的临床意义
- Author:
Qin-Ping LIAO
;
Hong ZHENG
;
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Receptors;
progesterone;
Protein expression
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine PRA and PRB expressions at mRNA and protein levels in endome-trial carcinomas,and to correlate the PRA and PRB expressions in tumours with clinical features inclu-ding grading,surgical stage,degree of myometrial invasion,and lymph node status.Methods:Sixty-sixendometrial carcinomas were investigated with Western blot assays and reverse-transcription polymerasechain reaction.The corresponding clinical information was collected.Spearman's rank correlation wasused to test for association between expressions of total PR and PR isoforms in endometrial carcinomas andclinical features.Results:At protein level,expressions of PRA and PRB were significantly inversely re-lated to grade(r=-0.343,r=-0.310,P
