Therapeutic window of whole blood rapamycin concentration in recipients of renal transplantation
- VernacularTitle:雷帕霉素应用于肾移植受者药物浓度范围的研究
- Author:
Changxi WANG
;
Wenjun SHANG
;
Lizhong CHEN
;
Jiguang FEI
;
Bin REN
;
Shuxia LI
;
Keli ZHENG
;
Xiaoda TANG
;
Yu FAN
;
Zhilian MIN
;
Juan Qi
;
Zhihong LIU
;
Shuming JI
;
Leishi LI
;
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Rapamycin;
Drug concentration;
Acute rejection
- From:
Chinese Journal of Nephrology
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic window of rapamycin(RPM) concentration in primary recipients of renal transplantation. Methods An open label, multi center study was performed. One hundred primary renal allograft recipients with cadaveric donors were enrolled from 4 transplantation centers in China. The immunosuppressive regimen was triple therapy,i.e.RPM combined with CsA and steroid. A loading dose of RPM 6 mg/d was administered within 48 hours after transplantation, then a maintaining dose of 2 mg/d was administered. The whole blood concentration of RPM was measured by HPLC method. Results The whole blood concentration of RPM in this group was (6.65?2.75)ng/ml, the 10th and 90th percentile for RPM concentration was 3 2 ng/ml and 10 26 ng/ml,respectively.9 5%(8/84)patients suffered from acute rejection during the 6 month period after transplantation in this study, and the concentration of RPM in these was lower than that in non rejection patients(P=0.001). Hyperlipidemia and liver dysfunction were the most frequently adverse events, and RPM concentration was significantly associated with the concentration of triglyceride. Conclusions 4～8 ng/ml is a suitable level for RPM concentration. Regular drug monitoring and reasonable dose modulation may increase the validity and security of RPM.
