The relationship between polymorphisms of NRAMP1 gene and susceptibility to tuberculosis in Chinese Han nation
- VernacularTitle:中国汉族人群结核易感相关基因多态性研究
- Author:
Lingyun SHAO
;
Xinhua WENG
;
Zhongyi HU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
NRAMP1 gene;
Polymorphism, restriction fragment length;
Tuberculosis pulmonary;
Polymerase chain reaction
- From:
Chinese Journal of Infectious Diseases
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the relationship between polymorphisms of NRAMP1 gene and susceptibility to tuberculosis in Chinese Han nation by case control study. Methods We selected 127 patients with active pulmonary tuberculosis who were all Han people with mean age of 52.5 years and 58 ethnically matched healthy controls. We typed the polymorphisms of NRAMP1, INT4 and D543N, through polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) techniques. Results Two NRAMP1 polymorphisms were both significantly associated with smear positive pulmonary tuberculosis. Subjects who were heterozygous for polymorphisms in INT4 and D543N were related with tuberculosis. It was the cooperation of different polymorphisms of NRAMP1 that led to the susceptibility to tuberculosis. Conclusions The polymorphisms in NRAMP1 gene affect susceptibility to tuberculosis in Han people in China.
