Clinical effect of consensus interferon in the retreatment of previous nonresponders or relapsers of chronic hepatitis C
- VernacularTitle:复合干扰素治疗复发及无应答慢性丙型肝炎效果观察
- Author:
Xiaojuan LI
;
Yanyan YU
;
Chongwen SI
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Hepatitis C, chronic;
Recurrence;
Interferons;
Forecasting
- From:
Chinese Journal of Infectious Diseases
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of consensus interferon in previous nonresponders or relapsers of chronic hepatitis C as well as to compare the correlation between viral kinetics and the efficacy. Methods 32 patients who are previous nonresponders or relapsers to IFN received CIFN 15?g three times a week for 24 weeks. Efficacy was assessed by ALT and HCV RNA (viral kinetics) during the 24 weeks of treatment period and 6 month follow up post treatment. Results After 24 weeks treatment, HCV RNA negative rate in the previous nonresponders and the previous relapsers were 90% versus 45.5% ( P 0.05 ). The major adverse events were fever and leukopenia. Conclusions CIFN 15?g as a monotherapy significantly improved end of treatment response rate in chronic hepatitis C patients. Baseline serum HCV RNA load and early virus kinetics are predictive parameters of SR.
