Effects of simvastatin on myocardial fibrosis and connective tissue growth factor in renovascular hypertensive rats
- VernacularTitle:辛伐他汀对肾性高血压心肌纤维化及结缔组织生长因子的影响
- Author:
Yanwu WANG
;
Yongyan XIONG
;
Zhilong CHEN
;
Li LI
;
- Publication Type:Journal Article
- Keywords:
statins;
renovascular hypertension;
myocardial fibrosis;
connective tissue growth factor (CT-GF)
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of simvastatin on myocardial fibrosis and connective tissue growth factor (CTGF) in renovascular hypertensive rats. METHODS: The experimental rats were randomly divided into three groups, such as sham operation group rats, hyperpiesia rats and hyperpiesia rats treated with simvastatin (5 mg㎏kg -1 ?d -1 ). Systolic blood pressure (SBP) was measured and collagen concentration (Coll) was also detected in terms of hydroxyproline concentration. VanGieson and immunohistochemistry staining combined with computed morphometry were used to evaluate the total collagen volume fraction (CVF) and CTGF expression in left ventricular tissue. RESULTS: Compared with sham operation group rats, the SBP,CVF, Coll and CTGF expression increased markedly in hyperpiesia rats (P
