Effects of valsartan and spironolactone on insulin like growth factor-1 in cardiacmyocytes of spontaneously hypertensive rats
- VernacularTitle:缬沙坦和螺内酯对高血压大鼠心肌胰岛素样生长因子-1的作用
- Author:
Xiaochun DUAN
;
Jinming WANG
;
Fang WANG
;
Heng LI
;
Jinmei QIN
;
- Publication Type:Journal Article
- Keywords:
hypertensive;
cardiac hypertrophy;
insulin-like growth factor-1;
valsartan;
spironolactone
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the inhibitive effects of valsartan and spironolactone on expression of insulin like growth factor 1 in cardiacmyocytes of spontaneously hypertensive rats. METHODS: 18 SHRs were randomly divided into 3 groups (n=6 in each): valsartan group treated with 30 mg?kg -1 ?d -1 valsartan, spironolactone group treated with 20 mg?kg -1 ?d -1 spironolactone, and control group treated with placebo. All were administrated by gastric perfusion. 6 WKY rats were served as control. After 13 weeks administration, the expressions of IGF 1 in cardiacmycytes were measured by immunohistochemistry and the IGF 1 concentrations in myocardium were measured by radiommunoassay. RESULTS: The expression of IGF 1 was higher in SHR group than that in the WKY group (P
