Effects of ulinastatin on inflammatory cytokines in blood serum of rats after severe burn and the significance
- VernacularTitle:乌司他丁对严重烧伤大鼠血清中致炎因子的影响及意义
- Author:
Kang XIE
;
Yuesheng HUANG
;
- Publication Type:Journal Article
- Keywords:
ulinastatin;
interleukin 1?;
interleukin 6;
tumor necrosis factor ?;
burn
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of ulinastatin (UTI) on the inflammatory cytokines in the blood serum of rats after severe burn. Methods A total of 96 SD rats, inflicted with 30% TBSA full thickness skin burn, were randomly divided into simple burn group (group B) and UTI treated group (group UTI). The serum contents of IL 1?, IL 6, and TNF ? were determined at 0, 1, 3, 6, 12, and 24 h before and after burn injury. Results In group B, the levels of serum IL 1?, IL 6, and TNF ? were significantly higher at 3 h and peaked at 6 and 12 h after burn. In group UTI, the levels of serum IL 1?, IL 6, and TNF ? were significantly lower than those in group B ( P
