Preparation of slowly released microspheres of dextro-ketoprofen-?-cyclodextrin inclusion
- VernacularTitle:右旋酮洛芬-?-环糊精微球的制备和体外释药研究
- Author:
Fengci HE
;
Liang CHEN
;
Desheng MENG
;
- Publication Type:Journal Article
- Keywords:
dextro ketoprofen;
microsphere;
dissolubility
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare microspheres of dextro ketoprofen ? cyclodextrin (S KP ? CD) for prolonging the drug releasing time in vitro . Methods Microspheres containing S KP ? CD were prepared by complex coacervation method with gelatin and acacia. Trap efficiency, drug loading, and drug content were determined. The dissolubility of S KP in the intestinal liquid was compared with that in the gastric liquid. Results In comparison with S KP, microspheres of S KP ? CD possessed slow releasing property. Conclusion Drug microspheres prepared by this simple, easy, and accurate method are of slow releasing property.
