Expression of brain-derived neurotrophic factor in the brain of old rats after chronic cerebral perfusion deficiency
- VernacularTitle:慢性脑灌注不足老龄大鼠脑内BDNF的表达
- Author:
Dong GAO
;
Jingzhou WANG
;
- Publication Type:Journal Article
- Keywords:
brain-derived neurotrophic factor;
vascular dementia;
cerebral ischemia;
cognitive dysfunction
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of expression of brain derived neurotrophic factor (BDNF) in the brain of old rats after chronic cerebral perfusion deficiency in the pathogenesis of vascular dementia. Methods Rat model of vascular dementia was established by modified Pulsinelli 4 vessel occlusion (4VO) and divided into 3d (3 d), 1 week (1 w), 2 weeks (2 w), 4 weeks (4 w) and 2 months (2 m) groups. Computer controlled initiative avoidance response shuttle box system was used to test the learning and memory capacity of rats. Immunohistochemical method was used to examine the expression of BDNF in CA1 region of the hippocampus and cortex of temporal and frontal lobe. Results Compared with those in control group, BDNF positive cells in CA1 region were decreased significantly in 4VO 1 w group ( P 0 05). Compared with those in the control group, BDNF positive cells in the cortex of temporal and frontal lobe were increased significantly in 4VO 3 d group ( P
