Changes of differentiation and proliferation of neural stem cells in rats treated with corticosterone
- VernacularTitle:皮质酮大鼠神经干细胞增殖分化的变化
- Author:
Chang GAO
;
Jingzhou WANG
;
- Publication Type:Journal Article
- Keywords:
Yougui Yin;
kidney Yang insufficiency syndrome;
neural stem cell;
differentiation;
proliferation
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of differentiation and proliferation of neural stem cells in rats treated with corticosterone (CORT). Methods Adult SD rats were administered with CORT (10 mg?kg -1 ?d -1 ) by consecutive subcutaneous injection for 14 days. Single and double immunohistochemical stainings were used to identify the neural stem cells and differentiated neural cells in adult rats. Results Compared with that in the normal control group, the number of BrdU immunohistofluorescence positive cells and BrdU+NF200, BrdU+NeuroD, BrdU+GFAP double immunostaining positive cells in the cerebral cortex, hippocampus, and hypothalamus were markedly decreased ( P
