Roles of hepatocyte cytochrome P450 2E1 in nonalcoholic steatosis of rat liver
- VernacularTitle:肝细胞色素P4502E1在大鼠非酒精性脂肪肝发生中的作用
- Author:
Lu HU
;
Dongfeng CHEN
;
Hongtao SHI
;
- Publication Type:Journal Article
- Keywords:
fatty liver;
cytochrome P450 2E1;
immunohisochemistry
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the roles of hepatocyte cytochrome P450 2E1 in model of nonalcoholic steatosis in rats Methods A total of 40 Wistar rats were randomly divided into two groups: control group (C) and high fat diet induced fatty liver group (H) The expression of hepatocyte cytochrome P450 2E1 antigen in rat model of nonalcoholic steatosis was detected by immunohistochemical method and Western blotting Malondialdehyde (MDA) contents were also determined Results MDA contents and the expression of hepatocyte cytochrome P450 2E1 antigen in rat model of nonalcoholic steatosis induced by high fat diet were higher than those in the normal controls ( P
