Study of the instability of microsatellite DNA and its relationship with clinical pathological parameters in esophageal cancer
- VernacularTitle:食管癌微卫星DNA不稳定性及其与临床病理的关系研究
- Author:
Kun YAN
;
Mingrong WANG
;
Dianchun FANG
;
Kang YANG
;
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
microsatellite instability;
PCR SSCP
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the state of microsatellite instability (MSI) and investigate the relationship between MSI and clinical pathological parameters in esophageal cancer. Methods MSI was analyzed by PCR SSCP method. Results MSI was detected (22 22%) in 45 cases of esophageal cancer. Effects of MSI on clinical stage, pathological classification, lymph node metastasis, and invasion were not found. Conclusion MSI may be an early molecular pathway and play a certain role in the development of the esophageal cancer.
