Prescription screening of dispersible compound melatonin tablets
- VernacularTitle:复方褪黑素分散片处方筛选的研究
- Author:
Qin GE
;
Jian CAO
;
Linqing HUANG
;
Enjuan ZHANG
;
- Publication Type:Journal Article
- Keywords:
melatonin;
dispersible;
disintegration;
dissolution;
prescription screening
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare dispersible compound melatonin tablets which can be quickly effective and used conveniently Methods The effective factors in the ingredients of the dispersible compound melatonin tablets were observed by orthogonal experiment design and the prescription was screened by disintegrating time limit Results The dispersible tablets could disintegrate completely in 50 seconds and the suspension could pass through 710 nm sifter in the dispersing test The dissolution rate could reach 92 9% in 5 minutes Conclusion The dispersible compound melatonin tablets can be prepared conveniently and easily disintegrate and dissolve
