Experimental study of arsenic trioxide on rabbits with hepatic Vx-2 carcinoma by transcatheter arterial infusion
- VernacularTitle:经兔肝动脉灌注As_2O_3对肝移植瘤作用的实验研究
- Author:
Mingyou ZHENG
;
Chengyi WU
;
- Publication Type:Journal Article
- Keywords:
arsenic trioxide;
transcatheter arterial infusion;
liver;
Vx 2 carcinoma;
rabbit
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the anticancer effect of arsenic trioxide (As 2O 3) on rabbits with hepatic Vx 2 carcinoma by transcatheter arterial infusion (TAI). Methods Rabbits with hepatic Vx 2 carcinoma were treated with As 2O 3 by TAI for 7 d consecutively. The tumor inhibitory rate and the average tumor weight were determined. The morphological changes of the tumor were observed with a transmission electron microscope. bax/bcl 2 and VEGF expressions were examined by immunohistochemistry. Results The average weight of the tumor was 7.99, 6.50, and 4.87 g, and the tumor growth inhibitory rates in the experimental groups were 50.31%, 59 58%, and 69 71%, respectively. Tumor growth was significantly inhibited as compared with that in the NS group ( P
