Functions,subunits and mechanisms of oxygen-sensitive potassium channels
- VernacularTitle:氧敏感钾离子通道的功能、亚型及氧敏感的可能机制
- Author:
Haixia ZHANG
;
Xiaoliang WANG
;
- Publication Type:Journal Article
- Keywords:
hypoxia;
cell reaction;
oxygen sensitive;
potassium channel
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Oxygen sensitive potassium channels can sense the change of oxygen pressure and mediate modifications in cell excitability,contractivity and secretory activity. Several oxygen sensitive K + channels subunits have been identified: Kv 1 2, Kv 1 4, Kv 1 5, Kv 2 1, Kv 3 1 b, Kv 3 3, Kv 3 4, Kv 4 2, Kv 4 3, Kv 9 3, K ATP , K Ca , TASK 1 and hTASK3. There are three mechanisms about the oxygen sensitivity of potassium channels. The subtypes and mechanisms of oxygen sensitive potassium channels variy from different cells and species. Discovery of the subunits of the oxygen sensitive potassium channels and their mechanisms might help to develop understanding and treatment of ischemic disorders, such as stroke, myocardial infarction, pulmonary hypertention as well as reperfusion injury.
