Effecet of intrathecal injection of 6-OHDA or ?_1-adrenoceptor antagonist on the spinal analgesia of ketamine
- VernacularTitle:鞘内注射6-羟多巴胺、?_1受体拮抗剂对氯胺酮脊髓镇痛作用的影响
- Author:
Zhijun GE
;
Tijun DAI
;
Yinming ZENG
;
- Publication Type:Journal Article
- Keywords:
ketamine;
spinal analgesia;
noradrenergic neurons;
? 1 adrenoceptor;
6-OHDA;
prazosin;
terazosin
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the relationship between spinal cord noradrenergic neurons ? 1 adrenoceptors and the spinal analgesia of ketamine. Methods Kunming mice were used. Analgesia tests were investigated with warm water tail flick test. The effects of intrathecal injection (ith) of ketamine (50,100,200 ?g)on tail flick latency of animals were observed. And the effect of pretreatment with intrathecal 6 hydrodoapa(6 OHDA, 6?g ) and ? 1 adrenoceptor antagonist prazosin (5, 15 ?g) or terazosin (5, 15 ?g) , respectively on the spinal analgesia of ketamine (100 ?g,ith) was studied. Results Dose dependent analgesia was observed following ith ketamine (100,200 ?g, P
