Influence of various absorption enhancers on the hypoglycemic effect of insulin via colon delivery
- VernacularTitle:促吸剂对胰岛素结肠给药降血糖作用的影响
- Author:
Chen XU
;
Junshou ZHANG
;
- Publication Type:Journal Article
- Keywords:
insulin;
eucalyptol;
absorption enhancer;
colonic absorption;
hypoglycemic effect
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim Effect of various absorption enhancers on the insulin colonic absorption was investigated. Methods The hypoglycemic effect was examined after colon delivery of INS SOL co administered with various absorption enhancers and the pharmacological bioavailability (PA) was calculated. Results INS SOL (5 U?kg -1 ) containing eucalyptol, sodium caprate, sodium deoxycholate and menthol significantly decreased the blood glucose level ( P
