Effects of melatonin and pentofylline on hepatic ischemia-reperfusion injury
- VernacularTitle:褪黑素和己酮可可碱减缓肝缺血再灌注损伤的实验研究
- Author:
Lixin ZHU
;
Hongchuan ZHAO
;
Peng DU
;
Xiaoping GENG
;
- Publication Type:Journal Article
- Keywords:
rat;
ischemia-reperfusion;
occlusion, melatonin;
pentoxifylline
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of melatonin (MT) and pentoxifylline (PTX) on hepatic ischemia reperfusion (I/R) in rat. Methods 128 rats were randomly divided into four groups: control group, MT treated group, PTX treated group and PTX+MT group (combined group). Those operation procedures including occlusion the inflow to the liver 35 minutes, hepatectomy and reperfusion, were underwent by the animals. The following items were investigated: liver function, endothelin 1 (ET 1), malondialdehyde (MDA), superoxide dismutase (SOD), and one week survival. Results The following changes were detected after the liver ischemia: ①Liver function: the increased scopes of ALT and LDH were significantly lower in treatment groups, especially in the combined group than that in control one; ②ET 1: the levers of ET 1 were significantly increased in every group, especially the control group; ③MT function: the increased scopes of MDA and SOD were significantly lower in MT groups (including MT treated and combined groups) than that in others; ④PTX function: the increased scopes of TNF ? were significantly lower in PTX groups (including PTX treated and combined groups) with a higher rate of survival than that in others. Conclusion ①MT could reverse the oxidative damage, but cannot affect the rate of survival; ②PTX can decrease the secretion of cytokine and the one week survival; ③Based on the synergistic effects, the application of MT+PTX may have beneficial effects against the I/R injury to increase the survival.
