Clinical study of the interferon ?-2b combined with kurorinone in the treatment of chronic hepatitis B
- VernacularTitle:干扰素?-2b联合苦参素治疗慢性乙型肝炎的临床研究
- Author:
Yiqun HUANG
;
Zhenhui LIN
;
Shumei JI
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Interferon Alfa 2b;
Matrine;
Hepatitis B,chronic;
Transforming growth factor beta;
Liver cirrhosis
- From:
Chinese Journal of Infectious Diseases
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of interferon ? 2b (IFN? 2b) combined with kurorinone in the treatment of chronic hepatitis B. Methods 146 patients with chronic hepatitis B were randomly divided into four groups(A,B,C,D). Based on the similar general treatment(group D),37 patients in group A was treated with IFN ? 2b and kurorinone. However, 37 patients in group B and 36 patients in group C received IFN ? 2b and kurorinone,respectively.Dynamic changes and relationships among liver histopathology,expression of TGF ? in liver tissue and serum levels of TGF ?,HBeAg,HBV DNA were studied using immunohistochemistry,radioimmunoassay and ELISA before and after treatment of IFN ? 2b and kurorinone. Results The score of histological hepatitic fibrosis,expression of TGF ? in liver tissue and serum levels of TGF ?,HBeAg, HBV DNA in group A showed significant lower than in group B and group C ( P
