The effects of glutamine on the splanchnic blood flow in rats with SAP
- VernacularTitle:谷氨酰胺对重症急性胰腺炎大鼠腹腔器官血流的影响
- Author:
Xuefeng XU
;
Dansong WANG
;
Wenhui LOU
;
Dayong JIN
;
Zhaohan WU
;
- Publication Type:Journal Article
- Keywords:
Glutamine;
Severe acute pancreatitis;
Blood flow
- From:
Parenteral & Enteral Nutrition
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To investigate the role of glutamine on splanchnic blood flow in SAP rats and underling mechanism. Methods: 32 rats were randomized divided into 2 groups:glutamine group(Gln group, n =16) and SAP group ( n =16).Jejunotomy was performed. Gln group received glutamine.SAP group received saline.All groups were subdivided into 2 groups.8 normal rats were used as the controls.At 12,24hours after the induction of SAP,8 rats in each group were sacrificed.Plasma glutamine concentrations were measured by HPLC.The regional pancreatic microvascular blood flow was measured by Dopplar ultrasound,the blood flow of portal vein,spleen artery and superior mesenteric artery was also measured. Results: Enterally administered Gln was well tolerated by the rats.There was an increase in plasma Gln levels after Gln supplementation on Gln group.The regional pancreatic microvascular blood flow decreased significantly in SAP group( P
