Functional and morphological differences between rat alveolar and interstitial macrophages
- VernacularTitle:大鼠肺泡和间质巨噬细胞的形态功能差异
- Author:
Wei ZHANG
;
Yaoguang JIANG
;
Deyu GUO
;
Chengxiang HU
;
Lei LI
;
- Publication Type:Journal Article
- Keywords:
pulmonary macrophage;
electron microscope;
phagocytosis;
rat
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the difference of morphology and phagocytosis between alveolar macrophages (AMs) and pulmonary interstitial macrophages (IMs). Methods AMs were collected by lung lavage and IMs by treatment of the lung tissue with DNAse and collagenase. The two cell populations were analyzed with respect to morphology by transmission electron microscopy, and the variation of these macrophages of phagocytosis were tested by malachite green colorimetry. Results There were great differences in morphology between AMs and IMs. The phagocytosis of AMs was much stronger than that of IMs. Conclusion There is functional and morphological heterogeneity between AMs and IMs. IMs should not be regarded as the precursors to AMs.
